Name:

LI, Lei

Subject:

Developmental Biology

Tel/Fax:

+86-10-64807865  / 

E-mail:

lil@ioz.ac.cn ，lleisep@gmail.com

Address:

The State Key Laboratory of Stem cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China

Resume:

Lei Li obtained his BS from China Agricultural University in 1994 and his Ph.D. from Gunma University Graduate School of Medicine in Japan in 2002. In 2003, he became a visiting fellow, then as a research fellow at National Institutes of Health (NIH) in USA where he mainly worked on mouse pre-implantation embryogenesis and ovarian development in the laboratory of Jurrien Dean. He established his independent research group in 2009 at the State Key Laboratory of Stem Cell and Reproductive Biology, Institutes of Zoology/Chinese Academy of Sciences. By using genetics, embryo culture and ES cells as model systems, Dr. Li's researches focus on molecular basis of early embryonic development.

Research Interests:

1) Maternal control of mammalian early embryogenesis.
2) Cell lineage specification of early embryonic development.
3) Molecular mechanism of mammalian gametogenesis.

Awards and Honors:

1) CAS“100 Talents”Program Recipient (IOZ/Chinese Academy of Sciences, China), 2009
2) NIH Fellows Award for Research Excellence (NIH, USA), 2007, 2008
3) Scientific Director Fellowship Award (NIDDK/NIH, USA), 2005
4) NIH Visiting Fellowship (NIH, USA), 2003-2008
5) Postdoctoral Fellowship for Foreign Researchers (JSPS, Japan), 2002-9/2003
6) Yoneyama Doctor Course Scholarship (Rotary Yoneyama Memorial Foundation, Japan), 4/2001-3/2002

Research Grants:

The National Basic Research Program of China (2011CB944501), 2011-2016.
National Natural Science Foundation of China (30971655), 2010-2012.
Grants of CAS “100 Talents” Program (Chinese Academy of Sciences), 2009-2012.

Selected Publications:

1. Liu W Wang F, Xu Q, Shi J, Zhang X, Lu X, Gao Z, Ma H, Zhao Z, Duan E, Gao F, Gao S*, Yi Z*, Li L*. BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis. Nature Communications. 2017 Jan 27; 8:14182.
2. Xiao Y, Ma H, Wan P, Qin D, Zhang X, Xiang Y, Wang X, Liu W, Chen J*, Yi Z*, and Li L*. Trp-Asp (WD) repeat domain 1 is Essential for Mouse Peri-implantation Development and Regulates Cofilin Phosphorylation. Journal of Biological Chemistry. 2017 Jan 27; 292(4):1438-1448.
3. Liu Y, Lu X, Shi J, Yu X, Zhang X, Zhu K, Yi Z, Duan E, Li L*. BTG4 is a key regulator for maternal mRNA clearance during mouse early embryogenesis.Journal of Molecular Cell Biology 2016 Aug; 8(4):366-8. 
4. Ma H, Lin Y, Zhao Z, Lu X, Yu Y, Zhang X, Wang Q*, Li L*.MicroRNA-127 Promotes Mesendoderm Differentiation of Mouse Embryonic Stem Cells by Targeting Left-right Determination Factor 2.Journal of Biological Chemistry 2016 Jun 3; 291(23):12126-35.
5. Xu Q, Wang F, Xiang Y, Zhang X, Zhao Z, Gao Z, Liu W, Lu X, Liu Y, Yu X, Wang H,  Huang J, Yi Z, Gao S*, Li L*. Maternal BCAS2 protects genomic integrity in mouse early embryonic development. Development. 2015 Nov 15; 142(22):3943-53.
6. Zhao Z-A, Yu Y, Ma H-X, Wang X, Lu X, Zhai Y , Zhang X-X, Wang H, Li L*. The roles of ERAS during cell lineage specification of mouse early embryonic development. Open Biology. 2015 Aug; 5(8).
7. Zhao B, Zhang W, Duan Y, Lu Y, Cun Y, Li C, Guo K, Nie W, Li L, Zhang R, Zheng P. Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability. Cell Stem Cell. 2015 Apr 29.
8. Zhu K, Yan L, Zhang X, Lu X, Wang T, Yan J, Liu X, Qiao J*, Li L*. Identification of a human subcortical maternal complex. Molecular Human Reproduction. 2015 Apr; 21(4): 320-9.
9. Yu X, Yi Z, Gao Z, Qin D, Zhai Y, Chen X, Ou-Yang Y, Wang Z, Zheng P, Zhu M, Wang H, Sun QY, Dean J*, Li L*. The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics. Nature Communications. 2014 Sep 11; 5:4887.
10. Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li B, Chen Q*, Duan E*, Wang H*. Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms. Cell Research. 2014 Aug; 24(8): 925-42.
11. Fu Z, Wang B, Wang S, Wu W, Wang Q, Chen Y, Kong S, Lu J, Tang Z, Ran H, Tu Z, He B, Zhang S, Chen Q, Jin W, Duan E, Wang H, Wang YL, Li L, Wang F*, Gao S*, Wang H*. Integral proteomic analysis of blastocysts reveals key molecular machinery governing embryonic diapause and reactivation for implantation in mice. Biology of Reproduction. 2014 Mar; 90(3): 52, 1-11.
12. Li L*, Lu X and Dean J*. The maternal to zygotic transition in mammals. Molecular Aspects of Medicine. 2013 Oct; 34(5): 919-38.
13. Xia P, Wang S, Du Y, Zhao Z, Shi L, Sun L, Huang G, Ye B, Li C, Dai Z, Hou N, Cheng X, Sun Q, Li L, Yang X, Fan Z*. WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. The EMBO Journal. 2013 Oct; 32(20): 2685-96.
14. Wang J, Xu M, Zhu K, Li L*, Liu X*. The N-terminus of FILIA forms an atypical KH domain with a unique extension involved in interaction with RNA. PLoS ONE. 7(1): e30209. Epub 2012 Jan 19.
15. Chen D, Zhang Y, Yi Q, Huang Y, Hou H, Zhang Y, Hao Q, Cooke HJ, Li L, Sun QY, Shi Q*. Regulation of asymmetrical cytokinesis by cAMP during meiosis I in mouse oocytes. PLoS ONE. 2012; 7(1): e29735.
16. Li L*, Zheng P and Dean J*. Maternal Control of Early Mouse Development . Development. 2010 Mar; 137(6): 859-70.
17. Li L*, Baibakov B and Dean J. A Subcortical Maternal Complex Essential for Pre-implantation Mouse Embryogenesis. Developmental Cell. 2008 Sep; 15(3): 416-25.
18. Ohsugi M, Zheng P, Baibakov B, Li L, and Dean J*. Maternally Derived FILIA/MATER Complex Localizes Asymmetrically in Cleavage Stage Mouse Embryos, Development. 2008 Jan; 135(2): 259-69.
19. Ogata T, Li L, Yamada S, Yamamoto Y, Tanaka Y, Takei I, Umezawa K and Kojima I*. Promotion of b-Cell Differentiation by Conophylline in Fetal and Neonatal Rat Pancreas, Diabetes. 2004 Oct; 53(10): 2596-2602.
20. Li L, Yi Z, Seno M, and Kojima I*. Activin A and Betacellulin: Effect on Regeneration of Pancreatic b-Cells in Neonatal Streptozotocin-treated Rats, Diabetes. 2004 Mar; 53(3): 608-615.
21. Li L, Seno M, Yamada H, and Kojima I*. Betacellulin Improved Glucose Metabolism by Promoting Conversion of Intra-islet Precursor Cells to-cells in Streptozotocin-treated Diabetic Mice, American Journal of Physiology-endocrinology and Metabolism. 2003 Sep; 285(3): E577-83.
22. Li L, Seno M, Yamada H, and Kojima I*. Promotion of β-cell Regeneration by Betacellulin in 90% Pancreatectomized Rats. Endocrinology. 2001 Dec; 142(12): 5379-85.