Name:

CHEN, Da-Hua

Subject:

Developmental Biology

Tel/Fax:

+86-10-64807325  / 

E-mail:

chendh@ioz.ac.cn

Address:

State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Siences, 1 Beichen West Road, Chaoyang District, Beijing 100101, P.R.China

Resume:

2008-Present Associate Director, State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
2007-2008 Associate Director, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences
2005-Present Professor, Institute of Zoology, Chinese Academy of Sciences
2003-2005 Instructor， Department of Molecular Biology，UT Southwestern Medical Center at Dallas.
2000-2003 Postdoc researcher, Department of Molecular Biology，UT Southwestern Medical Center at Dallas.
1999-2000 Postdoc researcher, Department of Agronomy, University of Kentucky.

Research Interests:

Germ cells are the only cells that are able to pass the genetic materials from one generation to the next. One of the most fundamental issues in developmental biology is how the germ cell development is regulated. The Drosophila and mouse germline system have provided heuristic models and brought many novel insights into the fields of germ cell developmental biology as well as stem cell biology.
Currently, we are integrating genetic, molecular biology and biochemical approaches to pursue in-depth understanding of the regulatory mechanism(s) underlying germ cell development and germline stem cell fate determination.
In the short-term, we are completing three ongoing projects: 1) understand molecular basis of protein modification in the regulation of germ cell development and germline stem cell fate; 2) elucidate molecular basis of translational control in germ cells; 3) to test the hypothesis of the potential crosstalk between protein modification regulation and translational control in germ cells.
The long-term goal of my lab is to identify novel mechanisms involved in Drosophila germ cells and germline stem cells, which will certainly help us elucidate how germ cell development and stem cell fate are controlled by the elaborate regulation of gene circuitry.

Professional Activities:

Reviewer for Journals: Current Biology; Development; Molecular Biology of the Cell; Genesis; JGG

Research Grants:

The start-up grant (role: PI) from Institute of Zoology, Chinese Academy of Sciences: Duration: (2005-2008).
The Chinese Academy of Sciences “One-Hundred-Talent Program”, Duration: ( 2007-2009).
The Chinese NSFC Key Project (role: PI), Research title: Mechanism of asymmetric division of germline stem cells regulated by the micRNA pathway, ( Grant Number: 30630042) Duration: (2007-2010).
The Chinese NSFC for “Excellent Young Scientist” (role: PI), Research title: Mechanism of development of germ cells in Drosophila, (Grant Number: 30825026) Duration: (2009-2012).
National Basic Research Program of China (role: PI), Research title: Identification of novel genes that control the fate determination of germline stem cells in Drosophila (Grant Number: 2007CB947502), Duration: (2007-2011).

Selected Publications:

1. Sun Q*, Huang S, Wang X, Zhu Y, Chen Z, Chen D*.(2015) N6 -methyladenine functions as a potential epigenetic mark in eukaryotes. Bioessays (Invited review)
2. Zhang G, Huang H, Liu D, Cheng Y, Liu X, Zhang W, Yin R, Zhang D, Zhang P, Liu J, Li C, Liu B, Luo Y, Zhu Y, Zhang N, He S, He C, Wang H*, Chen D* (2015) N(6)-methyladenine DNA modification in Drosophila.Cell 161: 893-906
3. Huang H, Li Y, Szulwach KE, Zhang G, Jin P*, Chen D* (2014) AGO3 Slicer activity regulates mitochondria-nuage localization of Armitage and piRNA amplification. The Journal of cell biology 206: 217-230
4. Zhu G, Li Y, Zhu F, Wang T, Jin W, Mu W, Lin W, Tan W, Li W, Street RC, Peng S, Zhang J, Feng Y, Warren StephenT, Sun Q*, Jin P*, Chen D* (2014) Coordination of Engineered Factors with TET1/2 Promotes Early-Stage Epigenetic Modification during Somatic Cell Reprogramming. Stem Cell Reports 2: 253-261
5. Huang S, Zhang Z, Zhang C, Lv X, Zheng X, Chen Z, Sun L, Wang H, Zhu Y, Zhang J, Yang S, Lu Y, Sun Q, Tao Y, Liu F, Zhao Y*, Chen D* (2013) Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover. PLoS biology 11: e1001721
6. Xia L, Zheng X, Zheng W, Zhang G, Wang H, Tao Y*, Chen D* (2012) The niche-dependent feedback loop generates a BMP activity gradient to determine the germline stem cell fate. Curr Biol 22: 515-521
7. Lu C, Lin L, Tan H, Wu H, Sherman SL, Gao F, Jin P*, Chen D* (2012) Fragile X premutation RNA is sufficient to cause primary ovarian insufficiency in mice. Human molecular genetics 21: 5039-5047
8. Xia L, Jia S, Huang S, Wang H, Zhu Y, Mu Y, Kan L, Zheng W, Wu D, Li X, Sun Q, Meng A, Chen D* (2010) The Fused/Smurf complex controls the fate of Drosophila germline stem cells by generating a gradient BMP response. Cell 143: 978-990
9. Yang Y, Xu S, Xia L, Wang J, Wen S, Jin P*, Chen D* (2009) The bantam microRNA is associated with drosophila fragile X mental retardation protein and regulates the fate of germline stem cells. PLoS genetics 5: e1000444
10. Jiang X, Xia L, Chen D, Yang Y, Huang H, Yang L, Zhao Q, Shen L, Wang J, Chen D* (2008) Otefin, a nuclear membrane protein, determines the fate of germline stem cells in Drosophila via interaction with Smad complexes. Developmental cell 14: 494-506