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Yingli, Sun

Yingli, Sun

Name: Yingli, Sun

Gender: Female





1991-09-1995-07: Bachelor, ShanDong University;

1995-09-2000-07:PH.D, Peking University;

 Work  Experience:


2000-08-2002-08: Post-PH.D, MIT(Massachusetts Institute of Technology);

2002-09-2010-08: Assistant researcher and lecturer, Harvard University Medical School Dana Farber Institute of Cancer Research

2010-09-Pre: Researcher, Beijing institute of genomics, Chinese academy of sciences

Research Area


Cancer genome and epigenome study

The relationship between epigenetic regulation and DNA damage repair pathways in tumor cells

Drug design and screening for specific epigenetic targets for tumor stem cells and tumor cells

Drug design and screening of repair pathways for tumor cell DNA damage

The genomic stability and epigenome of stem cells and tumor stem cells


 Selected Publications


1. Han X, Wang J, Sun Y*. Circulating Tumor DNA as Biomarkers for Cancer Detection, Genomics, Proteomics & Bioinformatics, 2017, 15(2): 59-72
2. Wang J, Chang S, Li G, Sun Y*. The application of liquid biopsy in precision medicine: opportunities and challenges, Frontiers of Medicine. 2017, doi: 10.1007/s11684-017-0526-7
3. Wang J, Han X, Sun Y*. DNA methylation signatures in circulating cell-free DNA as biomarkers for the early detection of cancer. Sci China Life Sci. 2017 Apr; 60(4):356-362.
4. Wu J#, Fu R#, Liu Z, Li G, Huang X, Xue Y, Xu Y, Sun Y *, Zhao J*, Mi J*,Cell proliferation downregulated by TGF-β2-triggered G1/S checkpoint in clinical CAFs. Cell cycle. 2017, Jan 17; 16(2):172-178.
5. Yang L, Wang YJ, Zheng LY, Jia YM, Chen YL, Chen L, Liu DG, Li XH, Guo HY, Sun YL, Tian XX*, Fang WG*. Genetic Polymorphisms of TGFB1, TGFBR1, SNAI1 and TWIST1 Are Associated with Endometrial Cancer Susceptibility in Chinese Han Women. PLoS One. 2016, 11(5): e0155270
6. Zhang M#, Wang C#, Yang C#, Meng H, Agbagwa IO, Wang LX, Wang Y, Yan S, Ren S, Sun Y, Pei G, Liu X, Liu J, Jin L*, Li H*, Sun Y*. Epigenetic Pattern on the Human Y Chromosome is Evolutionarily Conserved. PLoS One. 2016 Jan 13; 11(1):e0146402.
7. Yao L#, Ren S#, Zhang M#, Du F, Zhu Y, Yu H, Zhang C, Li X ,Yang C ,Liu H, Wang D, Meng H, Chang S, Han X, Sun Y*, Sun Y*. Identification of Specific DNA Methylation Sites on the Y-chromosome as biomarker in Prostate Cancer. Oncotarget. 2015, 6(38):40611-21.
8. Shu J#, Zhang K#, Zhang M#, Yao A, Shao S, Du F, Yang C, Chen W, Wu C, Yang W, Sun Y*, Deng H*. GATA Family Members as Inducers for Cellular Reprogramming to Pluripotency. Cell Res. 2015, 25(2):169-80.
9. Du F, Zhang M, Li X, Yang C, Meng H, Wang D, Chang S, Xu Y, Price B*, Sun Y*. Dimer monomer transition and dimer re-formation play important role for ATM cellular function during DNA repair. Biochem Biophys Res Commun. 2014, 452(4):1034-9.
10. Yao L#, Li Y#, Du F, Han X, Li X, Niu Y, Ren S*, Sun Y*. Histone H4 Lys 20 methyltransferase SET8 promotes androgen receptor-mediated transcription activation in prostate cancer. Biochem Biophys Res Commun. 2014, 450(1):692-6.
11. Du Y#, Wang J#, Jia J#, Song N#, Xiang C#, Xu J, Hou Z, Su X, Liu B, Jiang T, Zhao D, Sun Y, Shu J, Guo Q, Yin M, Sun D, Lu S*, Shi Y*, Deng H*. Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming. Cell Stem Cell. 2014, 14(3):394-403.
12. Zhang M, Yang C, Liu H, Sun Y*. Induced pluripotent stem cells are sensitive to DNA damage. Genomics Proteomics Bioinformatics. 2013, 11(5):320-6.
13. Xu Y, Parmar K, Du F, Price BD*, Sun Y*. The radioprotective agent WR1065 protects cells from radiation damage by regulating the activity of the Tip60 acetyltransferase. Int J Biochem Mol Biol. 2011, 2(4):295-302.
14. Ayrapetov MK, Xu C2, Sun Y2*, Zhu K, Parmar K*, D'Andrea AD, Price BD*. Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity. PLoS One. 2011, 6(10):e26064.
15. Liu Z, Sun Y*. Role of Tip60 Tumor Suppressor in DNA Repair Pathway. Chinese Science Bulletin. 2011, 56 (12): 1212-5.
17. Xu Y, Sun Y, Jiang X, Ayrapetov MK, Moskwa P, Yang S, Weinstock DM, Price BD*. The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair. J Cell Biol. 2010, 191(1):31-43.
18. Sun Y, Jiang X, Price BD*. Tip60: connecting chromatin to DNA damage signaling. Cell Cycle. 2010, 9(5):930-6.
19. Kim K, Pollard JM, Norris AJ, McDonald JT, Sun Y, Micewicz E, Pettijohn K, Damoiseaux R, Iwamoto KS, Sayre JW, Price BD, Gatti RA, McBride WH*. High-throughput screening identifies two classes of antibiotics as radioprotectors: tetracyclines and fluoroquinolones. Clin Cancer Res. 2009, 15(23):7238-45.
20. Sun Y, Jiang X, Xu Y, Ayrapetov MK, Moreau LA, Whetstine JR, Price BD*. Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. Nat Cell Biol. 2009, 11(11):1376-82.
21. Sun Y, Xu Y, Roy K, Price BD*. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. Mol Cell Biol. 2007, 27(24):8502-9.
22. Fernandes ND, Sun Y, Price BD*. Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells. J Biol Chem. 2007, 282(22):16577-84.
23. Sun Y, Jiang X, Chen S, Price BD*. Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation. FEBS Lett. 2006, 580(18):4353-6.
24. Jiang X#, Sun Y#, Chen S, Roy K, Price BD*. The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM. J Biol Chem. 2006, 281(23):15741-6.
25. Sun Y, Jiang X, Chen S, Fernandes N, Price BD*. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. PNAS. 2005, 102(37):13182-7.