Home People Changqing, Zeng

Changqing, Zeng

Changqing, Zeng

Name: Changqing, Zeng

Gender: male


E-Mail: czeng(AT)big.ac.cn

Education Experience


1978-1982: Bachelor,  Beijing Normal University;

1982-1985: Master, Beijing Normal University;
1987-1993: PH.D, University of Alabama at Birmingham;

Work Experience


1985-1987: lecturer, Beijing Normal University;

1994-2000: Research Associate Post-PH.D, Baylor college of medicine;

2000-2002: Assistant Professor,Houston medical college of University of Texas;

2002-2006: Researcher, Beijing genomics research center;

2003-2006: Professor, Beijing Normal University;

2003- pre: Researcher, Institute of Beijing genomics of CAS;

2010-2013:Director, Key laboratory of Serious disease and individualized medicine of Institute of Beijing genomics of CAS;

2014-pre: Director, Institute of Beijing genomics of CAS; The Key laboratory of accurate genomics medicine;

 Research Area


Tumor, disease related gene location and molecular pathway and regulation mechanism analysis,Population genetics studies and genomic functional notes of related genes such as hypoxia adaptation,Natural and disease-related somatic mutation studies,


 Selected Publications


1. Shao, J. M., Raza, M. S., Zhuoma B. S., Zeng, C. Q*. Evolutionary significance of selected EDAR variants in Tibetan high-altitude adaptations. Science China Life Sciences. doi: 10.1007/s11427-016-9045-7 (2017)

2. Zhang, H. K., Zhao, F. X., Hutchinson, D. S. et al., Zhang, D. K.*, Zhou, X. T. Conjunctival Microbiome Changes Associated With Soft Contact Lens and Orthokeratology Lens Wearing. Immunology and Microbiology. 58(1):128-136 (2016)

3. Li F, Zhang D, Li Y, Jiang D, Luo S, Du N, Chen W, Deng L, Zeng C*. Whole genome characterization of hepatitis B virus quasispecies with massively parallel pyrosequencing. Clinical Microbiology and Infection. (2015) Mar21 (3):280–287

4. Han X, Liu M, Wang S, Lv G, Ma L, Zeng C*, Shi Y. An Integrative Analysis of the Putative Gefitinib-resistance Related Genes in a Lung Cancer Cell Line Model System. Curr Cancer Drug Targets. (2015);15(5):423-34.

5. Xia H, Hu C, Zhang D, Tang S, Zhang Z, Kou Z, Fan Z, Bente D, Zeng C*, Li T. (2015) Metagenomic Profile of the Viral Communities in Rhipicephalus spp. Ticks from Yunnan, China. PLoS ONE 10(3): e0121609. doi:10.1371/journal.pone.0121609

6. Wu J, Li Q, Li Y, Lin J, Yang D, Zhu G, Wang L, He D, Lu G, Zeng C*. A Long Type of TBCK Is a Novel Cytoplasmic and Mitotic Apparatus-Associated Protein Likely Suppressing Cell Proliferation, Journal of Genetics and Genomics (2014), Feb 20;41(2):69-72.

7. Cheng F, Zhang X, Zhang Y, Li C, Zeng C*. Haplo2Ped: a tool using haplotypes as markers for linkage analysis, BMC Bioinformatics,(2011) 12:350.

8. Beall CM, Cavalleri GL, Deng L, Elston RC, Gao Y, Knight J, Li C, Li JC, Liang Y, McCormack M, Montgomery HE, Pan H, Robbins RA*, Shianna KV, Tam SC, Tsering N, Veeramah K, Wang W, Wangdui P, Weale ME, Xu Y, Xu Z, Yang L, Zaman MJ, Zeng C*, Zhang L, Zhang X, Zhaxi P, and Zheng YT (2010). Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders. PNAS, 107 (25): 11459-11464. (* corresponding)

9. Cheng F, Chen W, Richards E, Deng L, Zeng C* (2009). SNP@Evolution: a hierarchical database of positive selection on the human genome. BMC Evol Biol, 9:221.

8. Sun T, Gao Y, Tan W, Ma S, Shi Y, Yao J, Guo Y, Yang M, Zhang X, Zhang Q, Zeng C* & Lin D* (2007). A 6-nucleotide insertion/deletion polymorphism in the promoter of CASPASE-8 gene and susceptibility to multiple types of cancer. Nat Genetics, 39(5):605-613. (* corresponding)

9. Zeng C. as one principal investigator of the International HapMap Consortium (2007). A second generation human haplotype map of over 3.1 million SNPs. Nature, 449:851-861.

10. Zeng C. as one principal investigator of the International HapMap Consortium (2007). Genome-wide detection and characterization of positive selection in human populations. Nature, 449: 913-918